Mechanism of Action
XYREM® is a sodium salt of γ-hydroxybutyrate (GHB), an endogenous neurotransmitter and metabolite of GABA (γ-aminohydroxybutyric acid)
While the precise mechanism of action of XYREM is unknown, the effects may be mediated in part through interaction with GABAB and GHB receptors[3]
Source: [3]
To report an adverse event please call: 1-800-520-5568
References:
- ^ Muller C, Viry S, Miehe M, Andriamampandry C, Aunis D, Maitre M. Evidence for a γ-hydroxybutyrate (GHB) uptake by rat brain synaptic vesicles. J Neurochem. 2002;80:899–904.
- ^ Kaupmann K, Cryan JF, Wellendorph P, et al. Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice. Eur J Neurosci. 2003;18:2722–2730
- ^ Teter CJ, Guthrie SK. A comprehensive review of MDMA and GHB: two common club drugs. Pharmacother. 2001;21:1486–1513.
- ^ Mendelson WB. Hypnotic medications: mechanisms of action and pharmacologic effects. In: Kryger MH, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. 4th ed. Philadelphia, Pa: Elsevier; 2007:444-449.
- ^ Maitre M. The γ-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol. 1997;51:337–361.
