It is very important that you carefully read and follow all instructions before using Xyrem. Read this information carefully before you begin treatment. Read the information you get with each refill. There may be new information. This Medication
Guide does not take the place of talking with your doctor about your medical condition or your treatment or being familiar with the
other patient education materials. Your doctor must instruct you about the safe and effective use of Xyrem. If you have any questions about Xyrem, ask your doctor or call the central pharmacy at the toll free number 1-866-XYREM88® (1-866-997-3688). Do not throw away this Medication Guide. You may need to refer to it again later.
Xyrem is a prescription medicine used for the treatment of narcolepsy, to:
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and supplements. Especially, tell your doctor if you take other medicines to
help you sleep (sedatives). Sedatives should not be used with Xyrem.
See “Directions for using Xyrem” at the end of this Medication Guide for detailed information about taking
Xyrem can cause serious side effects, including:
The most common side effects with Xyrem are nausea, dizziness, and headache, vomiting, sleepiness and bed-wetting. An increase in side effects may happen with higher doses.
These are not the only possible side effects with Xyrem. If you are concerned about any possible side effects with Xyrem, talk
with your doctor.
Medicines are sometimes prescribed for purposes not mentionedin Medication Guides. Do not use Xyrem for a condition for which it was not prescribed. Do not give Xyrem to other people. It may harm them and it is against the law.
This Medication Guide summarizes the most important information about Xyrem. If you want more information, talk with your
doctor. You can ask your doctor for information about Xyrem that is written for health professionals. Also, you can call the central
pharmacy at the toll free number 1-866-XYREM88 (1-866-997-3688).
All Xyrem prescriptions are processed by a central, mail order pharmacy. The pharmacy staff provides several important services,
including the following:
Never leave your Xyrem in a place where children or pets can get to it.
Your Xyrem shipment will contain 1 or more bottles of medicine, 2 dosing cups with child-resistant caps, a liquid measuring device and this medication guide.
Remove the Xyrem bottle and the measuring device from the box (See Figure #1).
Remove the measuring device from the wrapper (See Figure #2).
Remove the bottle cap by pushing down while turning the cap counterclockwise (to the left). (See Figure #3).
After removing the cap, set the bottle upright on a tabletop.
While holding the bottle in its upright position, insert the tip of the measuring device into the center opening on top of the bottle and press down firmly (See Figure #4).
While holding the bottle and measuring device down with one hand, draw up the prescribed dose with the other hand by pulling on the plunger.
Note: Medicine will not flow into the measuring device unless you
keep the bottle in its upright position (See Figure #5).
Remove the measuring device from the center opening of the bottle. Empty each Xyrem dose into a dosing cup, then add about 2 ounces of water (60 mL, ¼ cup, or 4 tablespoons) to each cup (See Figure #6).
Prepare both doses before bedtime. Place the caps provided on the dosing cups and turn each cap clockwise (to the right) until it clicks and locks into its child-resistant position (See Figure #7).
Recap the Xyrem bottle and store it in a safe and secure place (locked up if needed), out of the reach of children and pets. Rinse out the liquid measuring device with water.
Right before going to sleep, place your second dose in a secure location near
your bed. Set an alarm to go off 4 hours after your first dose to wake you up for
your second dose. If you wake up before the alarm and it has been at least 2½
(2.5) hours, turn off your alarm and take your second dose.
Remove the cap from the first dosing cup by pressing down on the child-resistant locking tab (See Figure #8) and turning
the cap counterclockwise (to the left).
Drink all of the first dose right before bedtime (See Figure #9).
When you wake up 2½ (2.5) to 4 hours later, remove the cap from the second dosing cup. While sitting in bed, drink all of the
second dose right before lying down to continue sleeping. Recap the second cup.
Federal law prohibits the transfer of this drug to any person other than the patient for whom it was prescribed.
Jazz Pharmaceuticals, Inc.
Palo Alto, CA 94304
For questions of a medical nature or to order Xyrem call the Xyrem Patient Success Program® at 1-866-XYREM88 (1-866-997-3688).
Protected by US Patent Numbers 6780889, 6472431; additional patents pending. PSMG-01 Rev 1105 Part No. 002982
This Medication Guide has been approved by the US Food and Drug Administration.
Talk with a XYREM Patient Connection Mentor
The XYREM Patient Connection program provides an opportunity for you to talk one-on-one with a mentor who has been diagnosed with excessive daytime sleepiness and/or cataplexy with narcolepsy, and has been treated with XYREM.