Full Prescribing Information Important Safety Information Medication Guide

What is XYREM®?

XYREM is a prescription medicine used to treat the following symptoms in people who fall asleep frequently during the day, often at unexpected times (narcolepsy):

  • suddenly weak or paralyzed muscles when they feel strong emotions (cataplexy)
  • excessive daytime sleepiness (EDS) in people who have narcolepsy

XY REMmay only be given to patients enrolled in the XYREM Success Program.

XYREM is available only by prescription and filled through the central pharmacy in the XYREM Success Program. Before you receive XYREM, your doctor or pharmacist will make sure that you understand how to use XYREM safely and effectively. If you have any questions about XYREM, ask your doctor or call the XYREM Success Program® at 1-866-997-3688.

XYREM is approved in Adults. It is not known if it is safe and effective in children.

XYREM is a controlled substance (CIII) because it contains sodium oxybate that can be a target for people who abuse prescription medicines or street drugs. Never give your XYREM to anyone else because it may cause death or harm them. Selling or giving away this medicine is against the law.

Who should not take XYREM?

Do not take XYREM if you take other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Before you take XYREM, tell your doctor if you:

  • have short periods of not breathing while you sleep (sleep apnea)
  • snore, have trouble breathing, or have lung problems. You may have a higher chance of having serious breathing problems when you take XYREM.
  • have or had depression or tried to harm yourself. You should be watched carefully for new symptoms of depression.
  • have liver problems
  • are on a salt restricted diet. XYREM contains a lot of sodium (salt) and may not be right for you.
  • have high blood pressure, heart failure, or kidney problems.
  • are pregnant or plan to become pregnant. It is not known if XYREM can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if XYREM passes into your breast milk. You and your doctor should decide if you will take XYREM or breastfeed.

If you have been prescribed XYREM, see Getting Started with XYREM for information and tips on how to safely fill, take, and store your XYREM prescription.

To reach the pharmacy by phone please call:

 1-866-997-3688

To report a side effect
please call:

 1-800-520-5568


Jake S - Mentor

Talk with a XYREM Patient Connection Mentor

The XYREM Patient Connection program provides an opportunity for you to talk one-on-one with a mentor who has been diagnosed with excessive daytime sleepiness and/or cataplexy with narcolepsy, and has been treated with XYREM.

    The product information provided in this site is intended for residents of the United States only.