wHAT DO I NEED TO KNOw ABOUT PATHOPHYSIOLOGY?

wHAT DO I NEED TO KNOw ABOUT PATHOPHYSIOLOGY?

Narcolepsy is a serious neurological disorder.1-3

Narcolepsy pathophysiology.

  • The exact cause of narcolepsy is unknown.
  • Animal studies suggest that...
    • Narcolepsy may be due to dysregulation of a neuronal system which leads to the destabilization of the interaction between activating and inhibitory neurons.4-7
  • During the day...
    • Decreased signaling of activating/wake-promoting neurons may contribute to impaired wakefulness (excessive daytime sleepiness, or EDS) and muscle tone (cataplexy).5-9
EDS

EDS

EDS in narcolepsy may partly be the result of decreased signaling of dopaminergic and noradrenergic neurons.5,7,8

Cataplexy

Cataplexy

Cataplexy in narcolepsy may be the result of disrupted signaling of noradrenergic neurons.5,6,9,10