HOw DOES XYREM wORK IN MY BODY?

HOw DOES XYREM
wORK IN MY BODY?

XYREM has been shown to be rapidly absorbed and eliminated.1

In XYREM clinical studies...

  • Rapid absorption was observed, with absolute bioavailability found to be about 88%1:
    • Tmax: 30–75 min.
    • t1/2: 30–60 min.
  • Pharmacokinetics were nonlinear. Doubling the dose from 4.5 g to 9 g1,2:
    • Increased blood levels by 3.7-fold.1
    • Increased mean Cmax by 2.4- to 2.9-fold.2

Mean Oxybate Plasma Concentration in Healthy Volunteers2,3*

Mean Oxybate Plasma Concentration in Healthy Volunteers

*Mean oxybate concentration (±SEM) vs time after total doses of XYREM 4.5 g and 9 g administered in 2 equal doses given 4 hours apart in 12 healthy volunteers.

Single doses greater than 4.5 g have not been studied.

Dosage

Find out about how to
properly dose XYREM.

Starting &
Titrating XYREM
Counseling

Find out about counseling
patients on how to take
XYREM.

Setting a routine