XYREM is not available at your local pharmacy. As part of the XYWAV and XYREM REMS, XYREM is available only through a Certified Pharmacy. It is the only pharmacy in the United States permitted to fill the prescription and send directly to patients. The Certified Pharmacy is staffed by dedicated pharmacists who help caregivers learn how to use XYREM properly and make sure that your prescription is delivered securely.

Here are some highlights of the XYWAV and XYREM REMS:


  • Access to a pharmacist who is specially trained in the proper use of XYREM.
  • Available at any time, 24 hours a day, 7 days a week, to answer any questions about XYREM.


  • All XYREM shipments are made through an overnight delivery service so you can get it quickly.
  • Only you or a designated adult can sign for it.
  • Saturday delivery is available in most areas.
  • XYREM can be delivered right to your door, a local overnight carrier hub, or another location, if approved by the Certified Pharmacy.


  • Your healthcare provider will be notified when the first shipment is sent.
  • A JazzCares® Nurse Case Manager will contact you within 2 days of receiving the first shipment to answer questions.