SIMPLE, STEP-BY-STEP DOSING

I am the caregiver of
a child/adolescent

Preparing and taking your nightly XYREM doses

XYREM is a liquid that is taken at night divided into 2 doses: one at bedtime and another 2½ to 4 hours later. Both doses should be taken while in bed.

Read the Instructions for Use in the Medication Guide for detailed instructions on how to take XYREM. Follow the steps shown below to prepare your 2 nightly doses of XYREM.

In addition, help is always just a phone call away. You can always reach out to a JazzCares® Nurse Case Manager from the Certified Pharmacy, or your healthcare provider, if you have questions about how to take XYREM.

Setup

To prepare the dosage each night, you need:

  • 1 bottle of XYREM

    (the size and shape may vary, but the method of dispensing is always the same)

  • 2 empty pharmacy containers with child-resistant caps

  • 1 XYREM measuring syringe

  • 1 measuring cup able to measure ¼ cup of water (you will provide this item)

Before starting to prepare your child's doses, open each of the pharmacy containers and make sure both containers are empty and do not contain any medicine from the previous night's doses.

Preparing your XYREM doses

Measure each dose:

Hold the XYREM bottle down on the tabletop and firmly press the tip of the syringe into the opening on top of the XYREM bottle.

Now hold the bottle and syringe down with one hand and pull up on the plunger with the other hand to draw up your first nightly divided dose.

  • For example, if you have been prescribed a total nightly dosage of 4.5 grams divided into 2 doses of 2.25 grams, you will need to draw up 2 separate doses of 2.25 grams each, one for each pharmacy container.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: measure dose

Empty each dose:

After you draw up each separate XYREM dose, remove the syringe from the opening of the XYREM bottle. Empty each dose into its own pharmacy container by pushing down on the plunger.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: measure dose

Add water & close lids:

After emptying your first dose into its pharmacy container, use a measuring cup to pour about ¼ cup of water into the container. Then place the child-resistant cap onto the container and turn the cap to the right until it clicks and locks into its child-resistant position.

Repeat these steps when preparing your second dose.

Be careful to add only water to each container and not more XYREM. All shipped bottles of XYREM contain the concentrated medicine. Water for mixing the medicine is not provided in the shipment.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: measure dose

Store bottle:

Put the cap back on your XYREM bottle and store the bottle in a safe place out of the reach of children and pets. Rinse the syringe out with water and squirt the liquid down the drain.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: measure dose

Place nearby:

Before you take your first dose, put your second dose in a safe place, somewhere that is easy for you to reach. The doses should be out of the reach of children and pets. If for some reason you do not use a XYREM dose within 24 hours of mixing it with water, throw it away.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: measure dose

Learning anything new takes time. Remember, you have plenty of support. If you ever have any questions about your use of XYREM, call your doctor and feel free to contact a pharmacist from the Certified Pharmacy or a JazzCares® Nurse Case Manager.

Preparing your XYREM doses

Following these steps may help you establish a nightly XYREM routine. Be sure to read the Instructions for Use in the Medication Guide for detailed instructions on how to take XYREM.

Preparing Xyrem doses: measure dose

Measure each dose:

Hold the XYREM bottle down on the tabletop and firmly press the tip of the syringe into the opening on top of the XYREM bottle.

Now hold the bottle and syringe down with one hand and pull up on the plunger with the other hand to draw up your first nightly divided dose.*

•

For example, if you have been prescribed a total nightly dosage of 4.5 grams divided into 2 doses of 2.25 grams, you will need to draw up 2 separate doses of 2.25 grams each, one for each pharmacy container.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: empty dose

Empty each dose:

After you draw up each separate XYREM dose, remove the syringe from the opening of the XYREM bottle. Empty each dose into its own pharmacy container by pushing down on the plunger.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: add water

Add water & close lids:

Using a measuring cup, pour about ¼ cup of water into each container. Be careful to add only water to each container and not more XYREM. All shipped bottles of XYREM contain the concentrated medicine. Water for mixing the medicine is not provided in the shipment.

Repeat these steps when preparing your second dose.

Be careful to add only water to each container and not more XYREM. All shipped bottles of XYREM contain the concentrated medicine. Water for mixing the medicine is not provided in the shipment.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: close lids

Store Bottle:

Put the cap back on the XYREM bottle and store the bottle in a safe place out of the reach of children and pets. Rinse the syringe out with water and squirt the liquid down the drain.

See Instructions for Use in the Medication Guide.

Preparing Xyrem doses: store doses

Place nearby:

Before you take your first dose, put your second dose in a safe place, somewhere that is easy for you to reach. The doses should be out of the reach of children and pets. If for some reason you do not use a XYREM dose within 24 hours of mixing it with water, throw it away.

See Instructions for Use in the Medication Guide.

Learning anything new takes time. Remember, you have plenty of support. If you ever have any questions about your use of XYREM, call your doctor and feel free to contact a pharmacist from the Certified Pharmacy or a JazzCares® Nurse Case Manager.

Taking the doses

If you are prescribed XYREM, you should take the first dose once you are in bed for the night and at least 2 hours after eating. Then 2½ to 4 hours later, or as directed by your healthcare provider, take the second dose while still in bed. XYREM can cause sleep very quickly. Some people fall asleep within 5 minutes, and most people fall asleep within about 15 minutes. That is why you need to be in bed for each dose.

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